Chemist develops new drug to treat type 2 diabetes without undesired side effects

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Syracuse University chemistry professor Dr. Robert P. Doyle has developed a new drug lead to treat type 2 diabetes in millions of patients who are seeking to better control their blood sugar without the common side effects of nausea, vomiting, and in select cases, undesired weight loss.
Doyle's research article, "Corrination of a GLP-1 Receptor Agonist for Glycemic Control without Emesis," was published recently in the peer-reviewed scientific journal Cell Reports.

A common group of drugs used to treat type 2 diabetes are glucagon-like peptide-1 receptor (GLP-1R) agonists. While they do lower blood sugar levels in diabetic patients, their side effects include nausea, vomiting, and weight loss.

Through grants from the National Institutes of Health (NIH), Doyle and his collaborators found a way to combine two molecules into a new substance that lowers blood sugar without those undesired side effects.

In technical terms, Doyle's team developed a new area of bioconjugation, a chemical technique used to combine two molecules. By binding together exendin-4 (Ex4), an FDA-approved GLP-1R agonist, to dicyanocobinamide (Cbi), which is a small piece of the complex vitamin B12 molecule, they produced Cbi-Ex4 in a technique they call "corrination" - a play, of course, on…
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