Genetic basis of lacunar stroke: a pooled analysis of individual patient data and genome-wide association studies
Lacunar stroke has a substantial heritable component, with 12 loci now identified
that could represent future treatment targets. These loci provide insights into lacunar
stroke pathogenesis, highlighting disruption of the vascular extracellular matrix
(COL4A2, LOX, SH3PXD2A, GPR126, HTRA1), pericyte differentiation (FOXF2, GPR126),
TGF-β signalling (HTRA1), and myelination (ULK4, GPR126) in disease risk.