Guardian staff reporter

Police are investigating a social media post by Laurence Fox in relation to an "upskirting offence".

The tweet, posted on Tuesday, featured a compromising image of Narinder Kaur, a broadcaster on Good Morning Britain and GB News. The post remained on Fox's account until it was deleted on Thursday.

Posting on X, Kaur confirmed that it was now "a police matter" and said the image was "unimaginably mortifying" as she thanked people on the social media platform for their support.

"I know people are saying not to feel embarrassed and mortified but I am. I'm so incredibly upset that people are looking at my privates and laughing. It's unimaginably mortifying," she said.

A friend of the presenter told the Mirror: "Narinder has always been vocal about issues she cares about and while she's endured horrendous backlash before, she never expected to become the target of such vicious attacks."

The friend added: "Narinder deserves better than this. She's worked tirelessly to make her voice heard in among a male-dominated, increasingly rightwing rhetoric and this setback is crushing. She's determined to reclaim her dignity, no matter how daunting the challenge may seem."

The Metropolitan police told the PA news agency it was investigating the circumstances.

Upskirting – taking pictures of people under their clothes without their permission – became a specific criminal offence in 2019. Offenders can be jailed for up to two years and be placed on the sex offender register.

Kaur rose to fame on the second series of Big Brother, where she came in ninth place. She now regularly appears as a guest and presenter, including on GB News, Good Morning Britain and Jeremy Vine.

It comes a week after Fox was ordered to pay £180,000 in damages to two people he called "paedophiles" in a social media row, after losing a high court libel battle.

The former actor used to present on GB News but was fired in October after an on-air rant about journalist Ava Evans.

The PA news agency has contacted Fox for comment.

Post featured compromising image of the broadcaster Narinder Kaur, who said she was left 'incredibly upset'

Police investigate Laurence Fox 'upskirting' tweet  The GuardianLaurence Fox facing police probe after sharing upskirt picture of TV presenter  The IndependentLaurence Fox slammed after posting an indecent unearthed photo of TV host Narinder Kaur  The MirrorPolice probe right-wing politician Laurence Fox after he shared then deleted upskirt photo of presenter  LBCLaurence Fox reported by Big Brother star to police over 'upskirting' picture  Evening Standard

Police investigate Laurence Fox 'upskirting' tweet - The Guardian

Police investigate Laurence Fox 'upskirting' tweet

79d775129696bd7a77701d3c473f641911f64a15

Officers carrying out inquiries after message to author who voiced support for Rushdie following stabbing

Police investigate threat to JK Rowling over Salman Rushdie tweet

Traumatic nerve damage or compression neuropathy is the most common cause of unilateral weakness in an upper extremity. Rarely, a central nervous system lesion may cause syndromes that initially appear to indicate peripheral nerve injury. The most well known of these is pseudoperipheral hand palsy, which is typically brought on by a minor brain lesion in the contralateral motor cortex. The term "hand knob" refers to a restricted area in the posterior frontal lobe's precentral gyrus, a lesion that causes isolated weakness in the upper extremity that mimics injury to peripheral nerves. The majority of the time, an embolic infarction is the cause of this uncommon condition. We present a case of a 52-year-old female who presented to the medicine outpatient department with sudden onset of acute pure motor paresis of the right hand. She also complained of clumsiness in her hand and several episodes of generalized headache in the parieto-occipital region in the past two weeks. Following an initial evaluation by a physician, she was advised for MRI of the head and neck, which reported occlusion in the petrous part of the left internal carotid artery, and referred to physiotherapy for further management. She was assessed and a task-specific training protocol was made for the patient, which also included physiotherapy techniques like grip exercises, mirror therapy, and strengthening. There was an improvement in the patient within a few weeks that was evident with the outcome measures post-rehabilitation. This case study is really a good case not only in regards to peculiarities and clinical presentation but also in promoting rarely implementation of rehabilitation to get patients back to their previous functional status.

Positive Outcomes of Early Task-Specific Training and Action Observation Mirror Therapy Following Infarction of Hand Knob Area: A Case Report

This report discusses a case of a 37-year-old female who developed vaccine-induced thrombotic thrombocytopenia (VITT) after receiving the Johnson and Johnson COVID-19 vaccination. The patient first presented to the ED with complaints of a worsening headache. Labs were significant for thrombocytopenia with a platelet count of 22,000, and the patient was admitted to the inpatient unit for monitoring. The day after admission, the patient was found to have a right common femoral artery embolus, left distal popliteal trifurcation embolism, a small pulmonary embolism in the right lower lobe, and a mural thrombus of the infrarenal abdominal aorta. Following these findings, the patient underwent emergent thrombectomy of the common and superficial femoral arteries. Over the hospital course of six days, the patient received steroids and IV immunoglobulin (IVIG), which led to the resolution of the thrombocytopenia. The patient was given argatroban followed by apixaban for anticoagulation. She was instructed to follow up with hematology within one to two weeks post-discharge for monitoring of anticoagulation and thrombus surveillance. This case report outlines the clinical course, diagnosis, and treatment of a case of VITT, which will assist physicians in early recognition and adequate treatment of this condition as the COVID-19 pandemic continues.

A Case of COVID-19 Vaccine-Induced Thrombotic Thrombocytopenia

Hemorrhagic pericardial effusion is a rare presenting sign of undiagnosed rheumatoid arthritis (RA). We present a case of a 58-year-old female with a history of mucinous cystadenoma with subsequent omental caking status-post small bowel resection, chronic intermittent bilateral knee pain, carpal tunnel syndrome of the left hand, and drainage of a peritoneal inclusion cyst two days prior to admission. The patient had pleuritic chest pain and acute-onset shortness of breath but was hemodynamically stable on presentation. Transthoracic echocardiogram and CT scan demonstrated a large pericardial effusion measuring 1.5 cm anteriorly, 2.21 cm posteriorly, and 2.5 cm laterally. Diagnostic pericardiocentesis revealed a hemorrhagic pericardial fluid with a glucose level of 133 mg/dL, pH of 7.34, albumin of 2.6 g/dL, red blood cell count of 401,000 cells per cubic millimeters (CUMM), white blood cell count of 1,400 CUMM, lactate dehydrogenase (LDH) of 930 U/L, and protein of 5 g/dL. Infectious and malignancy workups were negative. Rheumatologic workup was positive for elevated rheumatoid factor and anti-cyclic citrullinated peptide. The patient was diagnosed with RA; she was started on methotrexate with folic acid, and a pericardial drain was kept in place for three days. We present a brief review of the workup, etiologies, and therapeutic approach for patients who present with hemorrhagic pericardial effusion secondary to undiagnosed RA.

Hemorrhagic Pericardial Effusion as the Presenting Symptom of Newly Diagnosed Rheumatoid Arthritis

p styletext-align justifyFollowing is a summary of current entertainment news briefsp
p styletext-align justifystrongQueen and Adam Lambert to bring Rhapsody Tour back to North Americastrongp
p styletext-align justifyBritish rockers Queen and US singer Adam Lambert are heading out on the road again bringing their updated and expanded Rhapsody Tour back to North America after four years Guitarist Brian May drummer Roger Taylor and Lambert announced on Friday they would return this autumn to the region where they first launched the tour in 2019p
p styletext-align justifystrongTrial witness against Theranos Elizabeth Holmes sues Disney Hulu over miniseriesstrongp
p styletext-align justifyA key prosecution witness whose testimony helped convict Theranos founder Elizabeth Holmes of fraud sued Walt Disney Co on Thursday over a recent Hulu miniseries that he says defamed him by portraying him as corrupt Adam Rosendorff a former Theranos lab director objected in a New York state court filing to a fictional character who held the same job in The Dropout which starred Amanda Seyfried as Holmes chronicling her rise and fall at the blood-testing startupp
p styletext-align justifystrongTop Gear filming halted after presenter Flintoffs car crashstrongp
p styletext-align justifyThe making of the hugely popular BBC car show Top Gear has been halted following a crash during filming in December that left co-presenter Andrew Freddie Flintoff with serious injuries the broadcaster said late on Thursday The BBC said it had concluded its investigation into the crash - which had initially led to filming being suspended - and that it would now halt filmingp
p styletext-align justifystrongGwyneth Paltrow testifies she was struck from behind in ski collisionstrongp
p styletext-align justifyOscar-winning actor Gwyneth Paltrow took the stand on Friday to testify that she was not at fault for a 2016 ski slope collision in Utah that left a man with a concussion and broken ribs contradicting testimony from the lone witness to the incident Paltrow 50 said during cross-examination that she was skiing with her two children and said that in fact she was struck by Terry Sanderson a 76-year-old retired optometrist who filed a lawsuit seeking more than 300000 in damages over the incident at the Deer Valley Resort in Utahp
p styletext-align justifystrongStarry Dungeons amp Dragons film brings fantasy game to big screenstrongp
p styletext-align justifyThe fantasy world of Dungeons amp Dragons came to a rainy Londons Leicester Square on Thursday as actors Chris Pine Rege-Jean Page and Michelle Rodriguez premiered their new film imagining of the popular role-playing game Dungeons amp Dragons Honor Among Thieves hits cinemas next week hoping to entice a new generation of fans with the game which first came out in 1974p
p styletext-align justifystrongReese Witherspoon agent husband make difficult decision to divorcestrongp
p styletext-align justifyOscar-winning actor and producer Reese Witherspoon and her talent agent husband Jim Toth said on Friday they had made the difficult decision to divorce The pair tied the knot in March 2011 at Witherspoons ranch in Ojai California northwest of Los Angeles In September 2012 the couple welcomed a baby boy named Tennessee Jamesp
p styletext-align justifystrongRust armorer attempts to block special prosecutors appointmentstrongp
p styletext-align justifyThe armorer charged in the New Mexico shooting death of Rust cinematographer Halyna Hutchins on Friday challenged the district attorneys plan to appoint a new special prosecutor in the case after the last one was forced to resign Special prosecutor Andrea Reeb resigned on March 15 after a legal challenge by lawyers for actor Alec Baldwin who has also been charged in the 2021 shooting Baldwin has pleaded not guilty to an involuntary manslaughter charge and armorer Hannah Gutierrez-Reed is expected to do the samep

Entertainment News Roundup: Gwyneth Paltrow testifies she was struck from behind in ski collision; Queen and Adam Lambert to bring Rhapsody Tour back to North America and more | Entertainment

For her work showing that restoring lost bacterial cues in the gut can stimulate development of insulin producing cells, potentially protecting against the autoimmune destruction associated with Type 1 Diabetes (T1D), Dr. Jennifer Hampton Hill is the winner of this year's NOSTER & Science Microbiome Prize.

"When we started this work, virtually nothing was known about the role of the microbiota in Type 1 Diabetes," said Hill. While it had been established that individuals with T1D have reduced microbiota diversity – suggesting they'd lost, or were never colonized with, specific bacteria that played important disease protection roles – her work goes a step farther, showing a particular bacterial protein found in rodent and human gut microbes can help restore insulin production.

"If we can continue to learn more about the mechanisms driving specific effects of the microbiota," she said, "I think we can … hopefully use that knowledge to treat many autoimmune diseases."

The NOSTER & Science Microbiome Prize awarded to Hill for her diabetes-focused work aims to reward innovative research from young investigators working on the functional attributes of the microbiota of any organism that has potential to contribute to our understanding of human or veterinary health and disease, or to guide therapeutic interventions.

"Submissions for the 2022 NOSTER/Science Prize have been outstanding," said Caroline Ash, senior editor at Science. "It is a great privilege to be given a glimpse of the fascinating, sophisticated and important research that today's generation of scientists is contributing to understanding the interactions of the microbiota with their hosts."

One-hundred years ago, Frederick Banting and Charles Best transformed the prognosis of Type 1 Diabetes through the discovery of the hormone insulin. But while scientists have made great progress in understanding diabetes, now known to be an autoimmune disease characterized by the destruction of insulin-producing beta-cells of the pancreas, no cure exists.

Treatment approaches for T1D focus on either restoring endogenous insulin or tempering autoimmunity. While there have been notable advances related to the former approach – restoring insulin – the field hasn't yet had much luck stimulating endogenous insulin renewal. One reason for this is the inconsistency in beta-cell physiology between rodents and humans.

"While mice and rats have a great deal of similarity with us, there are also important differences," Hill said. "These differences often become apparent when researchers test whether an exciting finding from a mouse islet translates to a human islet."

Hill explained that many in the field have found that human beta-cells are repeatedly recalcitrant to signals that robustly stimulated rodent cells. But she and colleagues identified a pathway to restoring insulin that stimulates rodent cells and holds promise for human beta-cells.

Hill and colleagues had hypothesized that because animals evolved in a microbial world, it is plausible that they used microbial cues to gather information about the environment, such as local nutrient availability, and set their metabolisms to match. They set out to investigate whether animals tune the number of cells producing insulin by incorporating information from their resident microbiomes.

To test this idea, Hill and her team used the zebrafish model to study development of pancreatic beta-cells with or without the microbiota. When comparing larvae grown in environments without microbes to their conventionally reared, microbe-carrying counterparts, they found that latter larvae had significantly more beta-cells than the microbe-free ones.

"We systematically added back individual zebrafish gut bacteria and their secreted products until we identified a single protein that was sufficient to restore GF beta-cell mass," said Hill. She and her teammates named this previously unknown protein beta-cell expansion factor A (BefA).

To test whether BefA elicited similar responses in mammalian species, they analysed beta-cell development in microbe-free mouse models. Adding purified BefA was enough to increase developing beta-cell mass in these animals, they showed.

"Because our discovery of BefA is highly conserved [across vertebrates]" said Hill, "we're optimistic about the potential of our discovery to overcome [existing] translational hurdles."

Why BefA evolved as a microbial product remains a question, she noted.

"We know BefA can bind to and disrupt cell membranes, which is a hallmark of an anti-microbial proteins (AMP), and bacteria tend to utilize AMPs as tiny weapons against other microbes…But we still don't fully understand the advantages that BefA production provides in the context of a complex microbial community," said Hill. "These are important questions to think about because if we can understand the circumstances that lead bacteria to produce BefA, we might be able to use that knowledge to boost natural BefA production in hosts more susceptible to disease."

Knowing BefA's mechanism for impacting beta cells could pave the way to researchers restoring or increasing beta cell production, said Hill, though she noted her own work has been focused on developing cells – and there are important differences between beta-cells from infants versus mature adults.

"We are currently working on experiments to evaluate the effects of BefA later in life, and on mature beta-cells," said Hill. "If BefA can promote the turnover or regeneration of mature adult beta-cells, it would be promising as a potential beta-cell replacement therapy."

The hygiene hypothesis that is often discussed today posits that certain diseases we are seeing more frequently, such as T1D, are the result of changing societal practices that have reduced microbial exposures and decreased microbiome diversity. Hill and her team suggest in their essay that fortification of these microbial activities in children who carry risk alleles for T1D could be a strategy to prevent or delay disease.

Hill was initially drawn to microbiology research through an inspiring undergraduate professor, Patty Siering, at Humboldt State University in California. "Working in her lab really revealed to me how much potential is hidden in the unexplored space of bacterial genomes."

Post-undergraduate, Hill completed a fellowship at the University of California San Francisco in Didier Stainier's lab working on zebrafish beta-cell regeneration, creating the unique path of research that would lead to her prize-winning research.

"[W]hen I started my dissertation in Karen Guillemin's lab at Oregon, who was an emergent leader in studying microbiota effects during development, it was sort of fortuitous to marry the only previous research experiences I'd had in microbiology and beta-cell development. And to our surprise, it was an idea with real legs!" Hill said.

Hill reflected on the significance of winning this prize in her research area. "There is amazing and fascinating work being done all across the microbiome field," she said, "and to be selected from it is a huge honor. I'm elated to be recognized, especially as a young scientist trying to establish my own niche. My work has been supported by remarkable mentors and colleagues, and it certainly wouldn't be possible without them. I'm incredibly grateful. It's a very exciting time to be studying the microbiota, and this award helps to draw attention to the innovation that this field has to offer."

"Controlling the microbiome is expected to contribute to the prevention and treatment of many chronic diseases," said Kohey Kitao, CEO of Noster Inc. "I truly hope that the prize will motivate young scientists to passionately pursue their research to develop microbiome-based therapeutic drugs for the benefit of human health and that world's children who will be the architects of the future of our Earth will be inspired by the wonders of scientific discovery."

Finalists:
Apollo Stacy is a finalist for his essay "Host-derived metabolite trains the microbiota to develop colonization resistance," which focused on analyzing the gut microbiota of previously infected mice, discovering that transient infection can enhance colonization resistance, and found that microbiota can be "trained" by infection-induced host metabolites. Stacy received his undergraduate degree from Washington University in St. Louis, PhD from The University of Texas at Austin, and is currently a postdoctoral fellow at the National Institutes of Health, starting his laboratory at the Cleveland Clinic Lerner Research Institute in 2022. His research investigates how host-derived metabolites shape ecological balance and thus host susceptibility to inflammatory disease.

Irina Leonardi is a finalist for her essay "Mycobiota modulate immunity and behavior," which focused on fungal communities as an integral part of gut microbiota and worked to demonstrate that mucosa-associated fungi are associated with host-protective immunity. Leonardi received undergraduate degrees from ETH Zürich and a PhD from the University of Zürich. She performed her postdoctoral work at Weill Cornell Medicine. Her research investigated the cellular mechanisms of fungal recognition in the gut and the local and systemic consequences of intestinal fungal colonization. She is currently the Scientific Communications Lead at Immunai in New York.