Cortical Surface Changes Tied to Movement Disorders in Schizophrenia

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Patients with schizophrenia and parkinsonism show distinctive patterns of cortical surface markers compared with their counterparts without parkinsonism and with healthy controls, results of a multimodal MRI study suggest.
Patients with schizophrenia and parkinsonism show distinctive patterns of cortical surface markers compared with their counterparts without parkinsonism and with healthy controls, results of a multimodal magnetic resonance imaging study suggest.

Dr Robert Christian Wolf

Sensorimotor abnormalities are common in schizophrenia patients, however, "the neurobiological mechanisms underlying parkinsonism in [schizophrenia], which in treated samples represents the unity of interplay between spontaneous and antipsychotic drug-exacerbated movement disorder, are poorly understood," wrote Robert Christian Wolf, MD, of Heidelberg (Germany) University, and colleagues.

In a study published in Schizophrenia Research (2021 May;231:54-60), the investigators examined brain imaging findings from 20 healthy controls, 38 schizophrenia patients with parkinsonism (SZ-P), and 35 schizophrenia patients without parkinsonism (SZ-nonP). Wolf and colleagues examined three cortical surface…
Heidi Splete
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