Professor Fu Yao and Associate Professor Lu Xi from the University of Science and Technology of China (USTC) have conducted a cobalt-hydride-catalyzed enantioselective hydroalkylation, enabling the efficient construction of chiral tertiary carbon centers at the benzyl position. The study has been published in Nature Synthesis.
This article has been reviewed according to Science X's editorial process and policies . Editors have highlighted the following attributes while ensuring the content's credibility: Credit: Nature Synthesis (2024). DOI: 10.1038/s44160-024-00581-x Alkyl carbon centers serve as scaffolds for 3D configuration in organic molecules and functional materials, endowing these molecules with unique properties and functions. Alkene hydroalkylation reactions make alkyl carbon centers by reacting metal hydride species with alkenes. However, controlling the stereochemical selectivity of this reaction has been challenging. The researchers investigated the…