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MIT researchers are expanding the capabilities of expansion microscopy — a high-resolution imaging technique the group introduced in 2015 — so researchers everywhere can see more when they look at cells and tissues under a light microscope.

/PRNewswire-PRWeb/ -- Scanning electron microscopy is an essential tool in advanced research, manufacturing, and quality control because of its ability to...

Li ion imaging by transmission electron microscopy (TEM) is the "holy grail" in the study of Li ion battery (LIB) materials. Tracking lithiation process in TEM could provide a more profound understanding of the electrode degradation mechanism during battery cycling, which accelerates material modification for better performance.

Motivated by the limitations of scanning approaches to photoacoustic microscopy, an international group supervised by Emmanuel Bossy of Université Grenoble Alpes experimented with structured illumination using known and unknown speckle patterns. One of their experiments produced the first demonstration of the use of blind structured illumination for photoacoustic imaging through a diffuser.

New research from Cornell offers insights into a line of CRISPR systems, which could lead to promising antiviral and tissue engineering tools in animal and plants.

EPFL scientists have developed a new research instrument for observing biological tissue samples prepared using a method discovered about forty years ago by Nobel Prize winner Jacques Dubochet, emeritus professor at the University of Lausanne. Their instrument—the only one of its kind in the world—opens up promising new avenues of research.

Photoacoustic imaging is a cutting-edge technology that uses light and sound to create images of the inside of the body. When a pulsed laser illuminates the surface of biological tissue, part of the photon energy is absorbed by the tissue to generate heat. The increase of the heat causes thermoelastic expansion of the tissue, releasing energy in the form of ultrasonic waves. By scanning the sample and collecting…

Unprecedented views of the interior of cells and other nanoscale structures are now possible thanks to innovations in expansion microscopy. The advancements could help provide future insight into neuroscience, pathology, and many other biological and medical fields.

Seeking to expand the possibilities offered by programmable illumination, a group of researchers at the University of Connecticut developed a strategy for constructing and calibrating freeform illuminators offering greater flexibility for computational microscopy. Their calibration method uses a blood-coated sensor for reconstruction of light source positions.

Researchers at Forschungszentrum Jülich and the Berlin Institute of Health at Berlin's Charité Hospital have developed a novel method for determining the number of subunits within protein complexes. The method is a further development of "super-resolution" single molecule localization microscopy (SMLM), whose developers were awarded the Nobel Prize in Chemistry in 2014. The new technique allows researchers to…

As an indispensable tool for observing the microcosmos, optical microscopy has boosted the development of various fields, including biology, medicine, physics, and materials. However, optical diffraction imposes a spatial resolution restriction on optical microscopy, which hampers exploration of finer structures.

An international team of scientists, led by Trinity College Dublin, has devised an innovative imaging method using state-of-the-art microscopes that significantly reduces the time and radiation required. Their work represents a significant breakthrough that will benefit several disciplines, from materials science to medicine, as the method promises to deliver improved imaging for sensitive materials such as…

New high-speed super-resolution imaging technique resolves a longstanding contradiction between spatial resolution and imaging speed

High-resolution microscopy techniques, for example electron microscopy or super-resolution microscopy, produce huge amounts of data. The visualization, analysis and dissemination of such large imaging data sets poses significant challenges.

Lipids—fats—make great walls for cells and organelles because they are water resistant and dynamic. But those same characteristics also make them hard to image using expansion microscopy, a technique that works for magnifying other cell components.

Proteins may be the most important and varied biomolecules within living systems. These strings of amino acids, assuming complex 3-dimensional forms, are essential for the growth and maintenance of tissue, the initiation of thousands of biochemical reactions, and the protection of the body from pathogens through the immune system. They play a central role in health and disease and are primary targets for…

Entangled biphoton sources exhibit nonclassical characteristics and have been applied to novel imaging techniques such as ghost imaging, quantum holography, and quantum optical coherence tomography. The development of wide-field quantum imaging to date has been hindered by low spatial resolutions, speeds, and contrast-to-noise ratios (CNRs). Here, we present quantum microscopy by coincidence (QMC) with balanced…

Using holograms created in digital microscopes and interpreted using artificial intelligence (AI), researchers can now follow the lives of microplankton at the individual level for the first time. The method is the result of an interdisciplinary research project at the University of Gothenburg.

Researchers have created a flexible needle-like endoscopic imaging probe that can acquire 3D microscopic images of tissue. The bendability is possible thanks to a new flexible graded index (GRIN) lens developed by the researchers.