PRMC-MS allows enhanced profiling of phosphoinositide acyl variants both in intracellular and extracellular environments.

Observational studies suggest a link between lipid levels and risk for dementia, but no clear pattern is seen. High and low levels of various lipids have been associated with both higher and lower risks.

Mitochondria release chemical energy and influence metabolic pathways that keep our cells and tissues healthy. Damage to these multifunctional powerhouses promotes cell death and disease.

Blood glucose, HbA1c also improved by week 12

An international team has discovered that the cellular balance of lipid droplets can impact the recycling of damaged mitochondria. These results have importance for cell survival and nervous system dysfunction.

The p97 protein is one of your body's best garbage disposers. It floats around in your cells looking for signals that a protein is past its shelf life and needs to be trashed. Mutations in this protein have been linked to neurodegenerative diseases, such as ALS and dementia, but p97's relationship to these disorders is still being explored.

New results from the SURMOUNT-1 trial of tirzepatide in people with obesity show further positive effects.

Researchers at Karolinska Institutet recently published a study in npj Biofilms and Microbiomes, that describes the properties of an enzyme that breaks down lipids.

Variability in total cholesterol, triglyceride levels at age 60 and older raised risk

Herbal teas are enjoyed worldwide, not only for their taste and refreshment but also for a wide range of reputed health benefits. But the potential significance of a category of compounds called lipids in the teas has been relatively unexplored.

Researchers have discovered a molecular pathway that allows cells to sense when their lipid supplies become depleted, prompting a flurry of activity that prevents starvation. The findings might someday lead to new ways to combat metabolic disorders and a variety of other health conditions.

CRISPR RNA is delivered to the mouse lung by inhalation using improved lipid nanoparticles.

Significant safety signals in dose-ranging trial may end drug's future in CV prevention

Neurons in the brain coexist with and rely on many other cell types to function properly. Astrocytes, which take their name from their star shape, ensure the survival of neurons by feeding and detoxifying them with the help of a multifunctional protein, APOE. One of three forms of this protein, APOE4, significantly increases the risk of developing Alzheimer's disease, but the mechanisms at play are unknown.

New-onset or pre-existing AF predicted acute ischemic stroke or TIA in patients with cancer -- as did renal disease, dyslipidemia, and active cancer therapy -- in a case-control study.

German chemicals group Evonik will build a U.S. production facility for lipids needed for mRNA therapies, winning considerable U.S. government backing for...

UT Southwestern researchers have discovered a molecular pathway that allows cells to sense when their lipid supplies become depleted, prompting a flurry of activity that prevents starvation. The findings, reported in Nature, might someday lead to new ways to combat metabolic disorders and a variety of other health conditions.

Soluble fibre is a type of fibre found in plant foods. Because it is not absorbed in the intestine, soluble fibre can bind cholesterol in the intestine and remove it from the body, says the American authority on lipids (Lipids.org). Eating 5 to 10 grams of soluble fibre a day can help lower total and LDL cholesterol by 5 to 11 points, and sometimes more. Read on to know more.

ABC transporters constitute a major class of multidrug resistance proteins, e.g., in cancer cells. Membrane lipids have been long known to influence the structure and functional dynamics of these proteins. However, previous structural and biochemical studies on ABCG2 are limited either by their static description or low spatial resolution to provide a microscopic view of the dynamics of the drug binding and lipid…

AbstractAims. Due to growing environmental focus, plant-based diets are increasing steadily in popularity. Uncovering the effect on well-established risk factor