The relation is relatively modest but strongly argues for increased testing of Lp(a) and adding atrial fibrillation as a secondary outcome to ongoing trials, experts say.

AbstractAims. Due to growing environmental focus, plant-based diets are increasing steadily in popularity. Uncovering the effect on well-established risk factor

The study "represents the beginning of our understanding of the role of Lp(a) in plaque progression," leading experts in lipoprotein(a) say.

The Eli Lilly drug caused a major drop in the blood levels of Lp(a), but further research is needed to show that it will prevent heart attacks and strokes.

Significant reductions in Lp(a) were sustained out to 150 days in patients without cardiovascular disease in top-line phase 1 results from the APOLLO study, released by Silence Therapeutics.

The prevalence of elevated low-density lipoprotein cholesterol has declined recently, but millions of Americans still have levels for which treatment is recommended or should be considered and many remain untreated.

The prevalence of subclinical hypothyroidism among adults with hypertension was 24%, compared with 17% among normotensive adults in a random sample of 2818 adults living in a single Chinese province.

Calcium scores and Lp(a) levels predict 10-year risk independent of each other, and together could swing shared decision-making about whether to start statins, researchers say.

Results from a small retrospective clinical study conducted in Singapore found that abrocitinib, baricitinib, and upadacitinib resulted in clearer skin and reduced itch.

Much of medicine relies on what is dubbed "small molecules". "Molecules" since they are atoms tightly bound together, forming what is easily seen as a unitary whole, as opposed to e.g. lipoproteins, which are synergistic ensembles held together by much weaker forces (pun not intended).

A new analysis illustrates, for the first time, a significant interaction between Lp(a) and hypertension in the primary prevention of cardiovascular disease.

"It's a new antibody that has a long half-life so each treatment can be prolonged."

Both very high and very low levels of high-density lipoprotein cholesterol were associated with an increased risk for diabetic kidney disease in women, but not men, with T2D.

An investigational PCSK9 inhibitor with a different mechanism from existing drugs in this class has been shown to safely and effectively lower cholesterol levels.

The hepatocyte-targeted small interfering RNA lowers triglyceride and other lipoprotein levels, and even reduces liver fat, report trial investigators.

Children and adolescents with homozygous familial hypercholesterolemia could benefit from lomitapide therapy, suggests a trial, although safety concerns and upcoming novel drugs question its place.

A drug targeting mRNA essential for APO C-III production provided a 50% reduction in triglycerides in BRIDGE-TIMI 73a, the largest ever observed in a controlled trial.

Data from four tirzepatide pivotal trials in people with type 2 diabetes showed ≥15% weight loss in 25% of those on tirzepatide, with seven factors significantly linked with greater weight loss.

After severe and cardioembolic stroke, poor oral hygiene is associated with elevated blood inflammatory cytokine levels, researchers warning.

The agency has okayed evinacumab-dgnb (Evkeeza) for patients aged 5-11 with homozygous familial hypercholesterolemia. It's already indicated for HoFH patients aged 12 and older.