Chimeric Antigen Receptor

Programmable RNA sensor and molecular tools refine therapeutic payload production

UK pharma group acquires Belgium's EsoBiotec as it announces EU has approved Imfinzi lung cancer drug

New therapies alter the traditional treatment paradigm

Represents the longest reported survival after CAR-T for an active malignancy

New York–based hematologist-oncologist and clinical researcher works to lower the barriers to enrolling in clinical trials.

DREAMM-7 findings help pave the way for Blenrep's return

A subgroup analysis showed that epcoritamab is effective regardless of CAR T–exposure in patients with R/R LBCL.

News, features, and commentary about cancer-related issues

Results of FELIX study supported obecabtagene autoleucel's recent FDA approval

A small trial used designer CAR T cells to reboot the immune systems of patients with three autoimmune diseases, but it's still too early to say whether the treatment works in the long term.

Obecabtagene autoleucel has no requirement for a REMS program

The premise of cancer immunotherapy is that cancers are specifically visible to an immune system tolerized to healthy self. The promise of cancer immunotherapy is that immune effector mechanisms and immunological memory can jointly eradicate cancers and ...

Results from the first-in-human trial of a new mRNA-based cancer vaccine are promising, as are early results from two other trials presented at ESMO.

Systematic review and meta-analysis finds CAR T-cell-specific toxicities only account for 11.5%

Patient achieves remission with biologic agent currently used for myeloma

Durable response possible with treatment targeting a different antigen

Also in TTHealthWatch: cancers subsequent to CAR-T therapy

Benefit with BV plus lenalidomide-rituximab seen in those who relapsed after CAR-T or transplant

News, features, and commentary about cancer-related issues

The bioengineered immune players called CAR T cells last longer and work better if pumped up with a large dose of a protein that makes them resemble stem cells