Phenotypic Screening

With the release of platforms like DALL-E 2 and Midjourney, diffusion generative models have achieved mainstream popularity, owing to their ability to generate a series of absurd, breathtaking, and often meme-worthy images from text prompts like "teddy bears working on new AI research on the moon in the 1980s."

MIT researchers built DiffDock, a diffusion generative model that could potentially find new drugs faster than traditional methods and reduce the potential for adverse side effects.

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A metabolite screen of pancreatic cells shows that pancreatic cancer cells metabolize uridine-derived ribose via UPP1, supporting redox balance, survival and proliferation.

Plant stomata are pores in the epidermis of plant leaves. They play a key role in regulating the gas-water exchange between the plant and the atmosphere, which enables photosynthesis and transpiration. Stomata have been shown to respond to a wide range of environmental conditions, including temperature, water availability, light intensity and leaf CO2 levels.

Researchers at University of California San Diego School of Medicine and Jacobs School of Engineering, with colleagues at Baylor College of Medicine, have used a systems biology approach to parse the genetic diversity of Clostridioides difficile, a particularly problematic pathogen in health care settings.

The cell is the basic structural and functional unit of life, with varying sizes, shapes, and densities. There are many different physiological and pathological factors that influence these parameters. It is therefore extremely important for biomedical and pharmaceutical research to study the characteristics of cells.

Researchers have used a systems biology approach to parse the genetic diversity of Clostridioides difficile, a particularly problematic pathogen, particularly in health care settings.