Tolerability

AXS-12, known as reboxetine back when it was available as an antidepressant in the United States, may decrease cataplexy attacks in narcolepsy, a phase 3 trial suggests.

A high omega-3, low omega-6 diet with fish oil led to a significant reduction in a biomarker for prostate cancer progression in men with prostate cancer on active surveillance.

Off-the-shelf drug reduces skin inflammation in animal models and human cell culture

Adults with hypoparathyroidism treated with TransCon PTH in the phase 3 PaTHway open-label trial extension demonstrated sustained efficacy, safety, and tolerability in a 1-year analysis.

In Novo Nordisk's randomized clinical trial, semaglutide reduced the risk for major adverse cardiovascular events by 14% compared with placebo.

A study of ruxolitinib cream in patients with lichen planus indicated that the topical JAK inhibitor is a promising potential treatment for cutaneous lichen planus that is also well tolerated.

The FDA has approved a first-in-class antipsychotic that targets cholinergic receptors without blocking dopamine receptors.

More noteworthy research from the EASD 2024 meeting

Newly approved prodrug has dual mechanism of action to improve tolerability

Maybe one of your patients is eligible for a new colorectal cancer clinical trial?

Lerodalcibep, a third-generation PCSK9 inhibitor, reduced LDL by more than 50% vs placebo in patients with or at a high risk for CVD in the phase 3 LIBerate-HR trial.

Vertex Pharmaceuticals said its medicine could address moderate to severe acute pain, and might be able to avoid the risk of addiction.

Selecting a treatment plan to deal with acute migraine attacks is like putting together a toolkit of possible therapies which can be individualized for each patient, one expert said.

Patients with breast cancer might be eligible to enroll in one of these clinical trials.

Trial tested BI 690517 with and without empagliflozin

In a letter, the FDA stated that additional efficacy data are required to support an approval for chronic spontaneous urticaria (CSU), according to the manufacturers of dupilumab.

Phase IIb trial shows benefit for the most common type of epileptic seizures

A meta-analysis of studies on the two diabetes drugs shows stronger benefits with tirzepatide, with the caveat of some higher gastrointestinal effects with tirzepatide.

Selective aldosterone synthase inhibitor proceeds to phase III study after Target-HTN's success

Phase II study misses main goal, but developer charts regulatory path around fatigue endpoint