N-Terminus

The findings suggested that higher doses of vitamin D3 supplementation do not reduce markers of subclinical cardiovascular disease in older adults with low serum vitamin D levels.

The study suggests that estetrol could be beneficial in reducing osteoporosis risk, but evidence of reduced fracture risk is still needed.

Several studies revealed high cardiovascular risk in people with type 1 diabetes, including in those who are asymptomatic and younger and with shorter diabetes duration.

In patients with HFpEF and obesity, symptom reduction and weight loss provided by semaglutide extends to those with diabetes, suggest new data from the STEP-HFpEF DM trial.

Biologic should arrive on pharmacy shelves before May

The Barostim neuromodulation system is now indicated in NYHA class III or class II HF despite guideline-directed medical therapies, with LVEF ≤ 35% and NT-proBNP < 1600 pg/mL.

Novel two-cutoff approach may reduce need for confirmatory PET scans

Drugs to treat cancer are often very expensive to produce, resulting in high costs for the patients who need them. Thanks to pathbreaking research by UCLA chemists, led by organic chemistry professor Ohyun Kwon, the price of drug treatments for cancer and other serious illnesses may soon plummet.

Sau3AI is a type II restriction enzyme widely used for genetic manipulation, such as genome library construction. Sau3AI consists of two domains, the N-terminal domain (Sau3AI-N) and the C-terminal domain (Sau3AI-C). How these two domains work together to cut DNA remains unclear.

Researchers perform extensive multiscale investigations to explore virological characteristics of the SARS-CoV-2 Omicron XBB subvariant, XBB.1.16.

But the tool performed well on cardiovascular trivia and answering patient questions

Pezeshkian et al. modeled the structure of SARS-CoV-2 envelope with near atomistic detail using an integrative multi-scale computational approach, highlighting the dynamic nature and molecular interactions of abundant but understudied M protein. Molecular dynamic simulations revealed а previously unknown property of M dimers: they agglomerated into large, filament-like, macromolecular assemblies.

Shigella bacteria can infect humans but not mice. In the March 29 issue of Nature, a team from UConn Health explains why. Their findings may explain the multifariousness of a key weapon of our immune system.

A team of researchers, including members from the University of Connecticut, has developed a nanoparticle-based treatment that targets multiple culprits in glioblastoma, a particularly aggressive and deadly form of brain cancer.

Prolonged cognitive deficits ("brain fog") following COVID19 infection (long-COVID) are common and debilitating, yet there are currently no approved t…

Early detection remains elusive, but treatments are reducing deaths

Tumors escape killing by the immune system through generating transient spatial cell-in-cell structures that are impenetrable to cytotoxic compounds including lytic granules and chemotherapy.

Insulin-like growth factor (IGF) is a hormone that greatly influences growth in fetuses and children, but also body maintenance and metabolism in adults. IGF regulates cell proliferation, differentiation, and survival by activating IGF receptors distributed in cell membranes of various tissues. However, IGF is so unstable that its half-life is less than 10 minutes in its free state.

Multiple variants of SARS-CoV-2 are inhibited by a trispecific DARPin.

Add HF to the list of cardiovascular conditions associated with periodontitis