Ex Vivo

Evidence showing the SARS-CoV-2 virus directly infects coronary atherosclerotic plaques, causing a persistent inflammatory response, may lead to new approaches for managing patients after infection.

A team of leading Croatian researchers at the Center of Excellence in Reproductive and Regenerative Medicine, Zagreb School of Medicine, has made a novel discovery in our understanding of limb development and DNA methylation, with potential implications for the field of regenerative medicine. The study's principal investigator, Vedrana Mužić Radović, along with senior researcher Ana Katušić-Bojanac, have led an…

Gene therapies treat or prevent disease by tweaking the content or expression of cells' DNA.

Time is of the essence when it comes to organ transplants. A few more hours or days could be the difference between life and death.

Proferroptotic activity of 7-dehydrocholesterol reductase is shown along with an unexpected prosurvival function of its substrate, 7-dehydrocholesterol, indicating a cell-intrinsic mechanism that could be used by cancer cells to protect phospholipids from oxidative damage and escape ferroptosis.

Scientists have made significant progress in understanding the signals involved in regulating oral keratinocyte cell motility and proliferative capacity, offering new insights into potential pharmacological manipulation for regenerative medicine. A recent study, published in FEBS Open Bio, explains the role of the epidermal growth factor (EGF) and its downstream signaling cascade in controlling the behavior of oral…

High rates of deep, durable response with bispecific antibody, rapidly produced CAR T-cell agents

Two human-derived proteins enhanced T-lymphocyte production from pluripotent stem cells; the advance may lead to a renewable supply of more affordable off-the-shelf immunotherapeutics.

'Outstanding' efficacy, 'life-changing' for transfusion-dependent patients, says panelist

Specialized immune cells generated in vivo reduce cardiac scar tissue in mice, a new study shows.

Two studies offer some reassurance on CAR T-cell therapy and checkpoint inhibitor safety

Six CAR-T-cell therapies have been approved by the European Commission and the US FDA, and other T-cell therapies are being developed.

Animal experimentation may not be a thing of the past just yet, but work on human iPS cell technology may someday grant emancipation for lab mice and other species.

Metabolite reprogramming observed in donor hearts after circulatory death and prior to transplant suggests exciting possibility for improved biomarkers to assess DCD heart quality.

INB-100 treatment has achieved durable 100% complete remission (CR) in treated patients, including high-risk acute myeloid leukemia (AML) patients and a...

This technique could permanently change the landscape of organ donation.

Visikol offers a unique multiplex platform for imaging tissues for 10+ IHC markers at a time and will be able to add genetic spatial imaging to this multiplex protein imaging data on a single slide through its partnership with Molecular Instruments.

While cross-reactive immunity between human coronavirus and SARS-CoV-2 may contribute to host protection, validating evidences are still scarce. Here the authors assess a cohort of 52 donors with immediate-early contact with SARS-CoV-2 to correlate higher frequency of cross-reactive T cells with lower infection rate.

The initiative will ensure the availability of a drug that otherwise would have been abandoned as unprofitable.

The advantages are huge if such a drug could be proven to work well—a lack of hospital and laboratory work would save a patient thousands