Substitution Reaction

Recently, a Chinese research team led by Prof. Guo Chang at the University of Science and Technology of China (USTC) of the Chinese Academy of Sciences (CAS) managed to catalyze an asymmetric propargyl substitution reaction with a nickel-derived catalyst, successfully synthesizing a series of chiral dienes in a diversified route.

From life-saving drugs and synthetic polymers to diverse advanced materials, the products containing organic compounds seem endless, thanks in part to regioselectivity, a feature in chemical reactions where a substituent is selectively added to a specific position of an organic compound. This favors the formation of desired products with specific functionalities.

A collaboration between Associate Professor Tsuda Akihiko's research group at Kobe University's Graduate School of Science and AGC Incorporated has succeeded in synthesizing various useful compounds from perchloroethylene (also known as tetrachloroethylene), a solvent commonly used to dry clean clothes.

Alkenes represent one of the most abundant classes of organic molecules, which are available in bulk quantities from petroleum and renewable resources, with various utilization in agrochemistry, pharmacy, and organic materials. Typically, the transformation of alkenes by cleavage of both the σ bond and π bond underpins a range of industrial processes and provides methods for the reconstruction of hydrocarbon…

Tobias Ritter and his team have developed a methodology that can be used to form anti-Markovnikov products. This might be helpful to tackle synthesis problems. Their work has now been published in Nature Catalysis.

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An international research team, led by NIMS, including Institute for Molecular Science (IMS) and Aalto University in Finland, has succeeded in synthesizing a two-dimensional silicon-integrated covalent organic framework (COF) film on a metal surface. This nanostructure was obtained by linking molecules and silicon atoms using a novel on-surface chemical reaction. This synthesis technique may potentially be…