Gram-Positive

Antimicrobial peptides have not typically lived up to their promise, especially when it comes to beating antibiotic resistance, but novel avenues could see them reach the clinic yet.

Researchers at Washington University School of Medicine in St. Louis have developed a novel compound that effectively clears bacterial infections in mice, including those that can result in rare but potentially fatal "flesh-eating" illnesses. The compound could be the first of an entirely new class of antibiotics, and a gift to clinicians seeking more effective treatments against bacteria that can't be tamed easily…

Since the 1970s, modern antibiotic discovery has been experiencing a lull. Now the World Health Organization has declared the antimicrobial resistance crisis as one of the top 10 global public health threats.

A new class of antibiotics for a drug-resistant bacterium was discovered using AI.

Traditional antibiotics drive bacteria toward drug resistance, so scientists are looking to viruses, CRISPR, designer molecules and protein swords for better treatments.

The antibiotic acts on not one but three molecules that are essential to the construction of bacterial walls.

Bacteria are intimately involved in our daily lives. These microorganisms have been used in human history for food such as cheese, yogurt, and wine. In more recent years, through metabolic engineering, microorganisms been used extensively as microbial cell factories to manufacture plastics, feed for livestock, dietary supplements and drugs.

Article URL: https://www.science.org/content/blog-post/bullvalene-antibiotics-all-things Comments URL: https://news.ycombinator.com/item?id=35472401 Points: 1 # Comments: 0

A novel role for molecular nano-syringes found in the antibiotic-producing bacteria Streptomyces has been revealed.

Researchers have designed and synthesized analogs of a new antibiotic that is effective against multidrug-resistant bacteria, opening a new front in the fight against these infections.

Breakthrough technology company seeks to develop partnerships to bring groundbreaking antimicrobial technology to catheter manufacturers

In a paper published in National Science Review, a team of scientists critically summarize major advances in mineral-microbe interactions, including molecular mechanisms of interactions and macroscopic manifestations of such interactions through time. Major challenges and future research opportunities are identified.

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Mississippi is the first state to spot the Burkholderia pseudomallei bacteria in its soil.

Compared with the prepandemic period, US hospitals with medium and high rates of antimicrobial resistance showed higher levels of antibiotic use among both SARS-CoV-2 positive and negative patients.

Preventing pathogenic viral and bacterial transmission in the human environment is critical, especially in potential outbreaks that may be caused by the release of ancient bacteria currently trapped in the permafrost. Existing commercial disinfectants present issues such as a high carbon footprint. This study proposes a sustainable alternative, a bioliquid derived from biomass prepared by hydrothermal liquefaction.…

Pharmaceutical scientists at the National University of Singapore (NUS) have developed a novel chemical reaction that enables the precise functionalization of peptides and proteins. This approach could provide a useful tool for bioconjugation and drug discovery.

Food safety is a critical aspect of health, and understanding the risks associated with improper food handling and storage can prevent foodborne

Oral antibiotic has potential for inappropriate use, agency says

A study across 120 US hospitals showed hospital-acquired gram-negative resistant infections were 13% higher post pandemic than in 2018-2019.