Single-Cell Analysis

The new cells, which the scientists have dubbed killer innate-like T cells, differ in several notable ways from the conventional target of many immunotherapies.

Scaling down single-cell reactions to the nanoliter level is critical to minimize the risk of contamination, increase reaction efficiency, and reduce costs. Researchers from the Single-cell Center of the Qingdao Institute of Bioenergy and Bioprocess Technology of the Chinese Academy of Sciences have developed a centrifugally driven system for precise manipulation of nanoliter liquids in single-cell analysis,…

Cellular identity is defined by gene activity that drives intercellular communication and is pivotal to understand mechanisms underlying multicellular organisms. In a new report Abbas Ghaddar and a research team in biology, pediatrics, systems biology, genome sciences, bioengineering and cardiovascular research in the U.S., presented an atlas of gene activity of a fertile adult metazoan Caenorhabditis elegans at…

A research team led by Dr. Chaogu Zheng from the School of Biological Sciences at the University of Hong Kong (HKU) has made a significant discovery about the evolutionary age of different type of cells in a small animal called Caenorhabditis elegans (C. elegans). By using single-cell transcriptomic data and refined phylostratigraphy, the team determines the transcriptomic age of individual cells, which means they…

The identification, sorting and export of single bacterial cells rather than populations of them has long been incredibly complex, expensive and often just does not work without damaging the cells.

A new process, which is more effective and efficient than conventional methods, has the potential to significantly impact cancer diagnostics as well as other fields of research.

In cancer research, it all comes down to a single cell.

A unique patient who has survived a dozen different types of cancer tumors has scientists looking to harness their powers for treatments.

Research applying single-cell analysis techniques and comparisons to a cell atlas resource allowed researchers at the Babraham Institute to connect observed development defects caused by disrupted DNA methylation processes with an understanding of the cell types affected. This work, published in Genome Biology, builds on previous work undertaken with collaborators to establish a detailed cell atlas charting cell…

In a world-first, scientists from BGI-Research, Chinese Academy of Sciences, and a group of partners published a study in Nature, announcing the discovery of a transgene-free, rapid, and controllable method to convert pluripotent stem-cells into bona fide 8-cell totipotent embryo-like cells, paving the way for advances in organ regeneration and synthetic biology.