Transcriptomics

/PRNewswire-PRWeb/ -- Catholic nuns don't make a habit of participating in long-term studies on aging and dementia, but one notable exception has yielded...

MIT Professor Xiao Wang's research is focused on developing tools that pinpoint where in a cell different types of messenger RNA are translated into proteins — information that can offer insight into how cells control their fate and what goes wrong in disease.

"We found that our gut environment . . . plays a big role in keeping potentially harmful bacteria in check"

The molecular and cellular organization of the primate cerebellum remains poorly characterized. We obtained single-cell spatial transcriptomic atlases of macaque, marmoset, and mouse cerebella and identified primate-specific cell subtypes, including ...

Spatial transcriptomics has emerged as a powerful tool for in situ analysis of gene expression within tissues. However, current technologies still face several challenges, including high costs, limited field of view, and low throughput, significantly hindering their application in large-scale tissue research and the analysis of complex biological processes.

A pivotal study has decoded the genetic basis of olive oil production, revealing a key regulatory mechanism that shapes oil biosynthesis. By mapping the olive tree's genome and metabolic pathways, researchers have identified how MYC2, a critical transcription factor, orchestrates the balance between fatty acid and flavonoid synthesis. These insights open new avenues for breeding olives with superior oil profiles,…

Fusarium wilt is a severe threat to the global cut-flower industry, particularly impacting lilies. Caused by Fusarium oxysporum, this disease results in significant economic losses due to plant decay and death. Traditional breeding methods have struggled to create resistant varieties, largely due to the complex genetic and metabolic factors involved in disease resistance. Addressing these challenges requires…

The mouse is the most commonly used vertebrate experimental model in neuroscience research, and the new atlas paves the way for a greater understanding of the human brain.

In 2018, researchers in the Caltech laboratory of Yuki Oka, professor of biology and Heritage Medical Research Institute Investigator, made a major discovery: They identified a type of neuron, or brain cell, that mediates thirst satiation. But they were running into a problem: A state-of-the-art technique called single-cell RNA sequencing (scRNA-seq) could not find those thirst-related neurons in samples of brain…

Researchers have discovered a new hybrid brain cell, bridging the gap between neurons and astrocytes. This cell can release neurotransmitters and may influence conditions like epilepsy and memory consolidation, offering promising paths for neuroscientific research and potential treatments. Neuros

Researchers from around the world will be able to use this publicly available resource.

The new method uses an engineered extracellular matrix free of animal components, improving the neurogenesis of brain organoids.

PredxBio, the industry leader in Spatial Biology and Explainable AI for predicting disease progression, is pleased to announce the addition of Dr. Stanley Marks, Chairman of UPMC Hillman Cancer Center, to its Board of Directors.

Big changes often happen in small steps, and it's not always easy to see how we get from point A to point B. Now, researchers from Japan have found a new step in the process of cell differentiation that leads to the production of fully functional basophils, which are critical cells in the immune system.

An interdisciplinary team in Penn State's College of Agricultural Sciences—in an initiative aimed at better understanding the implications of climate change for animal and plant life and agricultural systems—is focusing on an emerging field of study called landscape transcriptomics.

Biomedical engineers and architects are collaborating on a project to create a living building façade that adapts to its environment. By studying plants, fetal chick hearts, and adult brain cancers, they aim to develop sustainable building designs and improve climate-adaptable plants, heart defect p

Alfalfa (Medicago sativa), commonly called the "King of Grass," is a legume grown in many parts of the world as a source of animal fodder. It is prized in the forage industry for its high protein content and biomass yield. Recently, alfalfa protein has found applications in aquaculture, pet food industry and human diet. Furthermore, it is seen as an environmentally beneficial crop, with positive impacts on…

Van Andel Institute scientists have developed a new extraction protocol for RNA-seq and metabolomic analysis, offering a more complete picture of cellular activity than either technique on its own.

A new study examines the regenerative potential of the human brain in aging and neurological diseases, which could provide an alternative to conventional strategies for enhancing or restoring brain function. Recent single-cell transcriptomic studies in the adult human hippocampus yielded conflicting results, and the researchers found that the design, analysis, and interpretation of these studies in the adult human…

Article URL: https://www.alzforum.org/news/research-news/parabiosis-illuminates-modifiable-pathways-brain-aging Comments URL: https://news.ycombinator.com/item?id=35122890 Points: 1 # Comments: 0