Stop Codon

Klunk and colleagues identify signatures of natural selection imposed by Yersinia pestis and demonstrate their effect on genetic diversity and susceptibility to certain diseases in the present day.

Programmable RNA sensor and molecular tools refine therapeutic payload production

Using an RNA sensor, MIT engineers have designed a new way to trigger cells to turn on a synthetic gene. Their approach could make it possible to create targeted therapies for cancer and other diseases, by ensuring that synthetic genes are activated only in specific cells.

Directed evolution creates new compact Cas9 variants that target most single pyrimidine nucleotide PAMs.

The genetic switch that 'really lets horses have their cake and eat it too.'

Strategy could keep potentially dangerous genes from escaping from genetically modified organisms

A new study suggests genetic changes allow horses to produce more energy, while minimizing the toll the energy takes on cells.

A genetic change that boosts a cell's aerobic capacity while also protecting it from excess stress could explain how horses became such powerful athletes, according to a new study in Science.

IL-2 cytokine therapy is made safer by splitting a designed mimetic in two for tumor targeting.

Gene testing does inform diagnosis, but it can't tell doctors when to intervene with prophylactic retinal treatments.

The activity of standard Cas9-based genome-editing systems can be constrained by the addition of cytosine stretches to the 5′-end of conventional single-guide RNAs.

Here using drug susceptibility profiling, genomics and evolutionary studies the authors provide strategies to exploit collateral drug responses in Mycobacterium tuberculosis to prevent the emergence of drug resistance.

Using an RNA sensor, MIT engineers designed a new way to trigger cells to turn on a synthetic gene. Their approach could make it possible to create targeted therapies for cancer and other diseases, by ensuring that synthetic genes are activated only in specific cells.

A SARS-CoV-2-human protein contactome map uncovers an inhibitor of viral replication.

Article URL: https://en.wikipedia.org/wiki/Gene_knockout Comments URL: https://news.ycombinator.com/item?id=32625830 Points: 1 # Comments: 0