Gel Electrophoresis

Swedish researchers develop origami-inspired nanorobots that successfully target and kill cancer cells in mice, offering potential for targeted cancer therapy.

In response to bacterial CRISPR–Cas immunity, phages and plasmids have evolved small non-coding RNA anti-CRISPRs, known as Racrs, that sequester Cas proteins in abberrant complexes and thereby inhibit immunity.

Multiple complementary DNA strands can be thermally annealed into desired entities to engineer DNA nanostructures. In a new study now published in Nature Nanotechnology, Caroline Rossi-Gendron and a team of researchers in chemistry, materials science and biology in France and Japan used a magnesium-free buffer containing sodium chloride, complex cocktails of DNA strands and proteins to self-assemble isothermally at…

Recent findings about collagen, our body's most abundant protein, reveal that its sacrificial bonds snap more quickly than the basic structure, thereby protecting the tissue as a whole - they track down harmful radicals that are produced during mechanical stress. One of the more unusual ways obje

Study investigates the occurrence of ADAMTS13 antibodies in COVID-19 patients and their association with disease severity and lower ADAMTS13 activity. The findings suggest the need to include ADAMTS13 antibodies in diagnosing and managing SARS-CoV-2 infections.

Many people use hydrogels without knowing it. As superabsorbents in nappies, for example, hydrogels absorb a lot of liquid. In the process, the initially dry material becomes jelly-like, but it does not wet. Some people place the swellable material on their eyeballs—soft contact lenses are also just hydrogels. The same goes for jelly and other everyday materials.

A novel role for molecular nano-syringes found in the antibiotic-producing bacteria Streptomyces has been revealed.

A team of undergraduate and graduate chemistry students in Jennifer Hines' lab at Ohio University recently uncovered a new class of compounds that can target RNA and disrupt its function. This discovery identified a chemical scaffold that could ultimately be used in the development of RNA-targeted medicines to treat bacterial and viral infections, as well as cancer and metabolic diseases.

Dr. Mrinalini Watsa, a researcher at San Diego Zoo, is developing an easy, cost-effective DNA analysis technique, using soil samples from the paw prints of 4-year-old Sumatran tiger Rakan. The application could one day help track endangered Sumatran tigers in the wild.

Hybridization chain reaction refers to an enzyme-free nucleic acid polymerization reaction. A target molecule triggers cascade hybridization reactions by several thermodynamically stable DNA fuel strands, producing ultra-long DNA nanostructures with nicks. Signal amplification of the target molecule can be achieved by the application of a hybridization chain reaction.

IL-2 cytokine therapy is made safer by splitting a designed mimetic in two for tumor targeting.

As usual, it's not quite what we were expecting

Correspondence from The New England Journal of Medicine — IL-1RA Antibodies in Myocarditis after SARS-CoV-2 Vaccination

In mammals, proteins called mucins evolved — again and again — by co-opting non-mucin proteins in a surprising way, study suggests.

To keep order in the tight quarters of the cell nucleus, our DNA is neatly clamped in place around a central disk by H1 linker histone, which helps shepherd DNA into the tidy chromatin fibers that comprise chromosomes. Linker histone, however, is far more than a mere protein clip. Without sufficient H1, the process of gene transcription falters and the intricate dance of DNA repair screeches to a halt. Perched…

Spirulina is used to manufacture a therapeutic antibody against campylobacter.

Intermittent fasting (IF) plays an essential role in improving lipid metabolism disorders caused by metabolic cardiomyopathy. Growing evidence revealed that N6-methyladenosine (m6A) RNA methylation is related to obesity and lipid metabolic. Our study aimed to assess the beneficial effects of IF on lipid deposition, apoptosis, and m6A methylation in high-fat diet (HFD)-induced obesity cardiomyopathy. Male C57BL/6J…

A long-held goal in sequencing has been to use a voltage-biased nanoscale pore in a membrane to measure the passage of a linear, single-stranded (ss) DNA or RNA molecule through that pore. With the development of enzyme-based methods that ratchet polynucleotides ...

MIT researchers are expanding the capabilities of expansion microscopy — a high-resolution imaging technique the group introduced in 2015 — so researchers everywhere can see more when they look at cells and tissues under a light microscope.

Some species of tardigrades are highly and unusually resilient to various extreme conditions fatal to most other forms of life. The genetic basis for these exceptional abilities remains elusive.