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Eliezer Masliah, a prominent neuroscientist and top NIH official steering billions in federal grant money, has "fallen under suspicion" of extensive academic fraud, writes Charles Piller at Science.org. The understated…

Health news and commentary gathered by MedPage Today staff

Scientific progress is built on experiments, data, research, and constant questioning. While fraud is not a new issue, big data and AI present challenges that dramatically increase the risk of fraud. New tools need to be developed to identify and reduce scientific fraud; without this, the foundation of the scientific process is at risk.

Tick bites are a concern usually associated with summer and hot weather, but experts warn that warmer winters could mean an uptick in ticks and Lyme disease.

A metabolite screen of pancreatic cells shows that pancreatic cancer cells metabolize uridine-derived ribose via UPP1, supporting redox balance, survival and proliferation.

Redo of landmark 2006 study is first step while U continues investigation of image manipulation.

Colistin is a cationic cyclic peptide that disrupts bacterial cell membranes of Gram-negative bacteria. It is one of the few remaining antibiotics of last resort for use against infections with multidrug-resistant bacteria. Hence, the recent global detection of transferable mobile colistin resistance gene families in a wide range of multi-resistant Gram-negative bacteria isolated from all kinds of…

Chronic alcohol consumption can increase sensitivity to pain through two molecular mechanisms. Researchers also identified potential new drug targets for treating alcohol-related chronic pain. Over half of people with alcohol use disorder (AUD) suffer from persistent pain, including alcoholic neuropathy. The study found that alcohol withdrawal could result in neuropathy that was not reversed by re-exposure to…

A major new study in the journal Nature reveals a 'traffic light' mechanism controlling genetic activity within cells—a system which could potentially be targeted by cancer drugs already in development.

A novel role for molecular nano-syringes found in the antibiotic-producing bacteria Streptomyces has been revealed.

Cognitive deficit is the main clinical feature of Alzheimer's disease (AD), and the massive death of neuronal cells is the leading cause of cognitive …

Background: Typical vivarium temperatures (20-26°C) induce facultative thermogenesis in mice, a process attributable in part to uncoupling protein-1 (UCP1). The impact of modest changes in housing temperature on whole body and adipose tissue energetics in mice remains unclear. Here, we determined the effects of transitioning mice from 24°C to 30°C on total energy expenditure and adipose tissue protein signatures.…

Photosynthesis is the means by which plants, algae, and cyanobacteria extract their "food" in the form of energy-rich biomolecules from sunlight, carbon dioxide, and water. It is a complex process, from which researchers are still coaxing many new details. A team led by LMU biologists Thilo Rühle, Bennet Reiter, and Prof. Dario Leister has now solved another piece of the puzzle of this essential process and…

Web sites and social media are exposing poor or fraudulent science, but often nothing happens after that: how should peer review work?

The SARS-CoV-2 protein ORF8 functions as a mimic of histone H3 to disrupt host cell epigenetic regulation.

As usual, it's not quite what we were expecting

Article URL: https://insight.jci.org/articles/view/127647 Comments URL: https://news.ycombinator.com/item?id=32544731 Points: 3 # Comments: 0

Lyme disease, a tick-borne illness, has doubled over the last decade—and climate change may play a leading role. Here's what to know.

Article URL: https://www.science.org/content/blog-post/more-fakery Comments URL: https://news.ycombinator.com/item?id=30947409 Points: 1 # Comments: 0

Brand, who "neither admits nor denies ORI's findings of research misconduct," agreed to have any research of hers funded by the Public Health Service supervised for 4 years.