Calcium in Biology

In the CodeBreaK 300 trial, sotorasib and panitumumab had better response rates and improved PFS vs standard-of-care treatment options.

Adults with hypoparathyroidism treated with TransCon PTH in the phase 3 PaTHway open-label trial extension demonstrated sustained efficacy, safety, and tolerability in a 1-year analysis.

Palopegteriparatide (Yorvipath) is a prodrug of parathyroid hormone administered once daily to provide stable PTH levels over 24 hours.

A road map for the vagal interoceptive system

A new study has shown that the interaction of miR-584-5p and RUNX2 could mediate PSC osteogenic differentiation induced by hypoxia. The work is published in the World Journal of Stem Cells.

Scientists have found that extracellular calcium mediates the activation of a membrane protein that waves the flag signaling cell death.

Engraftment arrhythmia (EA) compromises the safety of hPSC-CM cell therapy. We hypothesized that spontaneous graft depolarizations are the source of EAs. We used a CRISPR screen to demonstrate that targeting excitatory channels HCN4, CACNA1H, and SLC8A1 and expressing the inhibitory KCNJ2 channel generates quiescent-yet-excitable cardiomyocytes that engraft without resulting in EAs.

Researchers from Osaka University found that Ca2+ signaling simultaneously performed signal amplification and olfactory adaptation. The results demonstrated that this mysterious phenomenon was segregated inside the cilium. A novel system was used to observe changes in Ca2+ dynamics inside the thin structure of a cilium. Unveiling the mystery of Ca2+ signaling segregation further clarifies the mechanisms underlying…

Researchers uncover a previously unknown method of genome protection during replication. The safeguarding of cellular genomes is of utmost importance as any damage can result in cancer or cell death. The genome, consisting of the complete set of DNA, is at its most vulnerable stage during replicati

Agency said potential risk may require more frequent blood calcium monitoring

To hunt flies and other small animals, the Venus flytrap has to be faster than its prey. To do so, it has developed a catching organ that can snap shut in a fraction of a second and is controlled by the fastest signaling networks known in plants. An electrical signal known as the action potential is at the heart of this network. When a fly touches one of the six sensory hairs of the Venus flytrap, an action…

Kidney function and bone turnover may worsen in patients who are coinfected with HBV and HIV and take tenofovir disoproxil fumarate (TDF), researchers report.

Floods of calcium that originate from hippocampal neurons can also boost learning, a new study reports.

Seals, dolphins, and seabirds are becoming ill and dying in disturbing numbers on West Coast beaches. The culprit is an algae-based toxin named domoic acid. The way this works is fascinating.

Libraries around across the U.S. are helping people get healthier

Palopegteriparatide will be the only drug targeting underlying cause of rare endocrine disorder

This Review examines the interplay between the nervous system and tumours, from cancer initiation to progression and metastasis.

Also: Studies on some vitamin supplements, including vitamin D, show little benefit

But drug remains in regulatory limbo

Learn about some of the projects that the Mansoor Lab at OHSU is working on.