American Type Culture Collection

The Department of Health and Human Services has announced over $500 million in awards to help advance vaccines and therapeutics.

XBB is the first recombinant, globally dominant variant of SARS-CoV-2. Here, the authors examine the variant's origins and virological properties, showing it is the first example of SARS-CoV-2 improving its fitness through recombination.

Recent Omicron SARS-CoV-2 subvariants independently acquire 5 key Spike mutations. Here, the authors evaluate the evolutionary importance of the 5 mutations and characterize the virological properties of variant BQ.1.1 harboring all 5 mutations.

Analyses of the proteomes of astrocytes and neurons in a cell-specific and subcompartment-specific manner reveal distinct roles for these cell types that are relevant to obsessive–compulsive disorder and perhaps other brain disorders.

Testing of combinations of cancer immunotherapies and conventional drugs yields promising leads.

Bile salt hydrolases encoded by the gut microbiome shape the bile acid pool, including microbial conjugated bile acids, which impact Clostridioides difficile infection in the murine gut.

The COVID-19 pandemic has resulted in a huge number of deaths from 2020 to 2021; however, effective antiviral drugs against SARS-CoV-2 are currently under development. Recent studies have demonstrated that green tea polyphenols, particularly EGCG, inhibit ...

They call it Legionella bononiensis: it is the 64th species of Legionella identified worldwide, the second to be isolated in Italy since the discovery of the pathogen. It was discovered in 2019 in a hotel facility by researchers from the Laboratory of Environmental Microbiology and Molecular Biology (MAb) at the University of Bologna.

A metabolite screen of pancreatic cells shows that pancreatic cancer cells metabolize uridine-derived ribose via UPP1, supporting redox balance, survival and proliferation.

IL-2 cytokine therapy is made safer by splitting a designed mimetic in two for tumor targeting.

Screening recombinases identifies tools for inserting large sequences into the human genome.

The SARS-CoV-2 protein ORF8 functions as a mimic of histone H3 to disrupt host cell epigenetic regulation.

Antibody pairs are made to act selectively on cells co-expressing two targets by engineering their Fc domains.

Experiments in mice show that designed epigenome editors that contain domains of transcriptional repressors can enable stable epigenetic silencing of Pcsk9, a gene with a role in cholesterol homeostasis, without inducing DNA breaks.

Certain bats species have previously been identified as ancestral sources of coronaviruses that infect humans but there is limited data on the genomic diversity or zoonotic potential of viruses infecting bats in the UK. Here, the authors use deep sequencing and in vitro assays to characterise coronaviruses recovered from 48 bat faecal samples.

Cancers with common KRAS mutations can be treated with an inhibitor of lysosomal acidification in mice.

SARS-CoV-2 neutralizing antibodies are readily detected with a biosensor.