Aplaviroc

Chemical compound
trends
OctoberNovemberDecember2021FebruaryMarch0500
alias
AK-602
GW 873140
GW873140A
mass
577.315 dalton
chemical formula
C₃₃H₄₃N₃O₆
physically interacts with
C-C Motif Chemokine Receptor 5…
media
canonical SMILES
CCCCN1C(=O)C(NC(=O)C12CCN(CC2)CC3=CC=C(C=C3)OC4=CC=C(C=C4)C(=O)O)C(C5CCCCC5)O
isomeric SMILES
CCCCN1C(=O)[C@H](NC(=O)C12CCN(CC2)CC3=CC=C(C=C3)OC4=CC=C(C=C4)C(=O)O)[C@@H](C5CCCCC5)O
Wikimedia Commons URL
Wikipedia creation date
2/16/2008
Wikipedia incoming links count
Wikipedia opening text
Aplaviroc (INN, codenamed AK602 and GSK-873140) is a CCR5 entry inhibitor that belongs to a class of 2,5-diketopiperazines developed for the treatment of HIV infection. It was developed by GlaxoSmithKline. In October 2005, all studies of aplaviroc were discontinued due to liver toxicity concerns. Some authors have claimed that evidence of poor efficacy may have contributed to termination of the drug's development; the ASCENT study, one of the discontinued trials, showed aplaviroc to be under-effective in many patients even at high concentrations.
Wikipedia redirect
AK602
AK-602
GSK-873140
Aplaviroc hydrochloride
C33H43N3O6
Wikipedia URL
CAS Registry Number
ChEMBL ID
ChemSpider ID
Guide to Pharmacology Ligand ID
InChIKey
KEGG ID
PubChem CID
UNII