St Patrick's High School is a Roman Catholic educational institution located in Saddar Town, Karachi, Pakistan. Founded in 1861 by the Jesuits, the institution is the second-oldest school in the city. Since 1950, it has been run by the diocesan clergy of the Archdiocese of Karachi. For the last 150 years, the school has produced well-known leaders and public figures, including two Presidents and two Prime Ministers of Pakistan, two Chief Ministers of Sindh, one deputy prime minister (of India) two Cardinals of the Catholic Church, and several Mayors of Karachi. The school is owned by the Roman Catholic Church and managed by the Catholic Board of Education in Pakistan.