Ligase

Class of enzymes which can form bonds between molecules
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Ligases
EC enzyme number
6.-.-.-
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Wikipedia creation date
10/25/2001
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In biochemistry, a ligase is an enzyme that can catalyze the joining of two large molecules by forming a new chemical bond, usually with accompanying hydrolysis of a small pendant chemical group on one of the larger molecules or the enzyme catalyzing the linking together of two compounds, e.g., enzymes that catalyze joining of C-O, C-S, C-N, etc. In general, a ligase catalyzes the following reaction: Ab + C → A–C + b or sometimes Ab + cD → A–D + b + c + d + e + f where the lowercase letters can signify the small, dependent groups. Ligase can join two complementary fragments of nucleic acid and repair single stranded breaks that arise in double stranded DNA during replication.
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Ligases
Synthetase
Sythetase
Enzymatic ligation
Amide synthases
Ligase enzyme
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