The Agency for Science, Technology and Research (Abbreviation: A*STAR; Chinese: 新加坡科技研究局, Malay: Agensi Sains, Teknologi dan Penyelidikan) is a statutory board under the Ministry of Trade and Industry of Singapore. The agency supports R&D that is aligned to areas of competitive advantage and national needs for Singapore. These span the four technology domains of Advanced Manufacturing and Engineering (AME), Health and Biomedical Sciences (HBMS), Urban Solutions and Sustainability (USS), and Services and Digital Economy (SDE) set out under the nation's five-year R&D plan (RIE2020). The agency's research institutes are located mostly in Biopolis and Fusionopolis. The total strength of the A*STAR community, including scientists and researchers, technical and non-technical staff, and industry development and commercialization staff was 5,400.